Most of us are familiar with the common types of diabetes, especially type 1 and type 2.
However, type 3c diabetes mellitus (also known as pancreatogenic diabetes) is often overlooked and underdiagnosed.
This type of diabetes arises from damage to the pancreas, frequently linked to pancreatitis or other pancreatic diseases.
But how exactly does pancreatitis lead to type 3c diabetes, and why is it frequently misdiagnosed as type 2 diabetes?
In this article, I will explore the relationship between pancreatitis and type 3c diabetes, diving into the science behind it, the symptoms, and what makes type 3c diabetes so unique.
Pancreatitis refers to the inflammation of the pancreas, an organ responsible for producing enzymes that help digest food and hormones that regulate blood sugar, such as insulin.
Pancreatitis can be acute, occurring suddenly and often triggered by gallstones or excessive alcohol consumption, or chronic, where inflammation persists over time, often leading to permanent damage to the pancreas.
When the pancreas becomes inflamed, it fails to perform its normal functions.
Over time, repeated inflammation, particularly in chronic cases, can lead to scarring, tissue damage, and impaired hormone production, which are critical in controlling blood sugar levels.
Type 3c diabetes, also known as pancreatogenic diabetes (t3cdm), occurs when pancreatic damage disrupts the organ’s ability to produce insulin.
Unlike type 1 diabetes, where the immune system destroys insulin-producing cells, or type 2 diabetes, where the body becomes resistant to insulin, type 3c diabetes is a result of physical damage to the pancreas.
This damage can be caused by chronic pancreatitis, pancreatic surgery, pancreatic cancer, or cystic fibrosis.
Research published in The Lancet shows that approximately 9% of all diabetes cases are actually type 3c, but this figure is often underestimated because it is frequently misdiagnosed as type 2 diabetes.
A key difference is that individuals with type 3c diabetes often struggle with both the endocrine function (insulin production) and exocrine function (digestive enzyme production) of the pancreas.
This dual dysfunction makes type 3c diabetes distinct and more challenging to manage compared to other forms of diabetes.
Recognizing the signs of pancreatitis early on is crucial for preventing long-term damage that could lead to type 3c diabetes.
The signs of pancreatitis vary depending on whether it’s acute or chronic but often include:
When pancreatitis becomes chronic, the repeated damage to the pancreatic cells can trigger the onset of type 3c diabetes.
One hallmark feature of type 3c diabetes is that it appears several years after chronic pancreatitis has been present.
Pancreatogenic diabetes, or type 3c diabetes mellitus, results from the destruction of both the endocrine and exocrine functions of the pancreas.
As mentioned, this condition is often underdiagnosed, with many patients being incorrectly labeled as having type 2 diabetes.
Yet, the distinction is vital because treatment strategies for type 3c diabetes differ from those for type 2.
According to a 2020 study in Diabetes Care, patients with type 3c pancreatogenic diabetes have more complex needs, as they require both insulin replacement and enzyme supplementation to manage digestive issues.
This is why it is essential for clinicians to distinguish between type 3c diabetes and other forms of diabetes early in the diagnosis process.
Given the pancreas’s central role in both digestion and insulin regulation, issues with the pancreas can manifest in various ways.
Here are the 7 symptoms of pancreas problems that could signal pancreatitis or the risk of type 3c diabetes:
These symptoms, especially when chronic, may indicate damage to the pancreas, which could eventually lead to type iiic diabetes.
One lesser-known but important symptom of severe pancreatitis is Grey Turner sign, which refers to bruising on the flanks (the sides of the body between the ribs and hips).
This sign often indicates internal bleeding associated with acute pancreatitis, signaling a serious condition that requires immediate medical attention.
While Grey Turner sign is more commonly seen in acute, severe pancreatitis, its presence indicates the potential for significant pancreatic damage, which could contribute to the development of diabetes mellitus 3c over time.
Diagnosing type 3c pancreatogenic diabetes can be tricky because it shares so many characteristics with type 2 diabetes.
However, specific tests, such as imaging studies (CT or MRI scans) to assess pancreatic damage and blood tests to check for exocrine insufficiency (such as low fecal elastase levels), can help differentiate type 3c diabetes from other forms.
Treatment for type 3c diabetes typically involves:
While these treatment strategies help manage the symptoms, they do not reverse pancreatic damage, emphasizing the importance of early intervention for pancreatitis to prevent the onset of 3c diabetes.
In conclusion, pancreatitis is indeed a significant and often hidden cause of type 3c diabetes mellitus.
Chronic pancreatitis damages the pancreas over time, impairing both insulin and digestive enzyme production, leading to the onset of f3c diabetes.
Unfortunately, this type of diabetes is often misdiagnosed as type 2, meaning many patients do not receive the proper treatment they need.
Recognizing the early signs of pancreatitis and seeking appropriate medical care can help prevent the progression of pancreatic damage and reduce the risk of developing type iiic diabetes.
If you have experienced chronic pancreatitis or other pancreatic issues, it is essential to speak to your healthcare provider about the possibility of pancreatogenic diabetes.
While there is no cure for type 3c diabetes, early detection, taking a natural Blood Sugar Support Supplement and treatment can improve quality of life and help manage symptoms effectively.
References: